TRANSLATIONAL PHYSIOLOGY CALL FOR PAPERS Energy Homeostasis and Metabolic Diseases High-fat diet induces site-specific unresponsiveness to LPS-stimulated STAT3 activation in the hypothalamus
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چکیده
Beatriz de Carvalho Borges, Rodrigo Rorato, Ernane Torres Uchoa, Paula Marangon, Glauber S. F. da Silva, Francisco José de Paula, Luiz G. S. Branco, José Antunes-Rodrigues, and Lucila Leico Kagohara Elias Department of Physiology and Department of Internal Medicine, School of Medicine of Ribeirao Preto, University of Sao Paulo, Brazil; and Department of Morphology, Physiology and Basic Pathology, Dental School of Ribeirao Preto, University of Sao Paulo, Brazil
منابع مشابه
High-fat diet induces site-specific unresponsiveness to LPS-stimulated STAT3 activation in the hypothalamus.
Hypophagia induced by inflammation is associated with Janus kinase (JAK)-2/signal transducer and activator of transcription (STAT) 3 signaling pathway, and leptin-mediated hypophagia is also mediated by JAK2-STAT3 pathway. We have previously reported that lipopolysaccharide (LPS) did not reduce food intake in leptin-resistant high-fat diet (HFD) rats but maintained body weight loss. We investig...
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Leptin-stimulated Stat3 activation in proopiomelanocortin (POMC)-expressing neurons of the hypothalamus plays an important role in maintenance of energy homeostasis. While Stat3 activation in POMC neurons is required for POMC expression, the role of elevated basal Stat3 activation as present in the development of obesity has not been directly addressed. Here, we have generated and characterized...
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Ciliary neurotrophic factor (CNTF) exerts anorectic effects by overcoming leptin resistance via activation of hypothalamic neurons. However, the exact site of CNTF action in the hypothalamus has not yet been identified. Using Cre-loxP-mediated recombination in vivo, we have selectively ablated the common cytokine signaling chain gp130, which is required for functional CNTF signaling, in proopio...
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Food habits have a serious role in the emergence of the diseases and inflammation that causes many kinds of diseases. Some case-control studies concluded that high animal fat and cholesterol in diet is associated with some neuroinflammatory diseases such as Parkinson and Alzheimer. High level of cholesterol and lipopolysaccharides(LPS) include the peripheral inflammation in the body. There is e...
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Obesity is now classically characterized by a cluster of several metabolic disorders, and by a low grade inflammation. The evidence that the gut microbiota composition can be different between healthy and or obese and type 2 diabetic patients has led to the study of this environmental factor as a key link between the pathophysiology of metabolic diseases and the gut microbiota. Several mechanis...
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تاریخ انتشار 2013